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José Marín-García M.D., Michael J. Goldenthal, Gordon W. Moe's Aging and the Heart: A Post-Genomic View PDF

By José Marín-García M.D., Michael J. Goldenthal, Gordon W. Moe (auth.)

ISBN-10: 0387740716

ISBN-13: 9780387740713

ISBN-10: 0387740724

ISBN-13: 9780387740720

Cardiac getting older, like getting older more often than not, is a posh strategy. various mobile and molecular adjustments give a contribution to the expression of the a number of phenotypes of getting older, "the various faces" of cardiac getting older. during this publication, the genetic and molecular foundation of cardiovascular getting older can be mentioned. moreover, a accomplished evaluate of the bioenergetic alterations that ensue in human and animal types of cardiac getting older in addition to present diagnostic and destiny healing modalities may be undertaken.

José Marín-García is Director, The Molecular Cardiology and Neuromuscular Institute, Highland Park, New Jersey.

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Extra resources for Aging and the Heart: A Post-Genomic View

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Huang TT, Carlson EJ, Gillespie AM, Shi Y, Epstein CJ. Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice. J Gerontol A Biol Sci Med Sci 2000;55:B5–B9 102. Mehlhorn RJ. Oxidants and antioxidants in aging. In: Timiras PS, editor. Physiological basis of aging and geriatrics. 3rd ed. Boca Raton, FL: CRC, 2003. p. 61–83 103. Brown-Borg HM, Rakoczy SG. Catalase expression in delayed and premature aging mouse models. Exp Gerontol 2000;35:199–212 104. Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M, Coskun PE, Ladiges W, Wolf N, Van Remmen H, Wallace DC, Rabinovitch PS.

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For a more comprehensive discussion on caloric restriction and aging, the reader is directed to Chapter 15. Gender Issues in Aging In a variety of organisms, including human, females live longer and sex-dependent genes influence life span [121–123]. The effect of a gene on a multifactorial trait is contingent on the physiological background in which the gene is expressed. If the age-related physiological scenario changes in 22 Post-Genomic View of Aging: Definitions, Theories and Observations males and females differently, the effects of a certain gene on disease or survival could vary between the sexes, which indicates that males and females may follow different pathways toward extreme longevity [124].

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Aging and the Heart: A Post-Genomic View by José Marín-García M.D., Michael J. Goldenthal, Gordon W. Moe (auth.)


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